A secreted WY-domain-containing protein present in European isolates of the oomycete Plasmopara viticola induces cell death in grapevine and tobacco species.
Identifieur interne : 000199 ( Main/Exploration ); précédent : 000198; suivant : 000200A secreted WY-domain-containing protein present in European isolates of the oomycete Plasmopara viticola induces cell death in grapevine and tobacco species.
Auteurs : Maud Combier [France] ; Edouard Evangelisti [Royaume-Uni] ; Marie-Christine Piron [France] ; David Rengel [France] ; Ludovic Legrand [France] ; Liron Shenhav [Royaume-Uni] ; Olivier Bouchez [France] ; Sebastian Schornack [Royaume-Uni] ; Pere Mestre [France]Source :
- PloS one [ 1932-6203 ] ; 2019.
Descripteurs français
- KwdFr :
- Analyse de séquence de protéine (MeSH), Clonage moléculaire (MeSH), Domaines protéiques (MeSH), Europe (MeSH), Interactions hôte-pathogène (MeSH), Maladies des plantes (microbiologie), Mort cellulaire (MeSH), Noyau de la cellule (métabolisme), Peronospora (classification), Peronospora (isolement et purification), Peronospora (métabolisme), Phylogenèse (MeSH), Protéines fongiques (composition chimique), Protéines fongiques (génétique), Protéines fongiques (métabolisme), Spécificité d'espèce (MeSH), Tabac (microbiologie), Vitis (microbiologie), États-Unis (MeSH), Évolution moléculaire (MeSH).
- MESH :
- composition chimique : Peronospora, Protéines fongiques.
- génétique : Protéines fongiques.
- isolement et purification : Peronospora.
- microbiologie : Maladies des plantes, Tabac, Vitis.
- métabolisme : Noyau de la cellule, Peronospora, Protéines fongiques.
- Analyse de séquence de protéine, Clonage moléculaire, Domaines protéiques, Europe, Interactions hôte-pathogène, Mort cellulaire, Phylogenèse, Spécificité d'espèce, États-Unis, Évolution moléculaire.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Cell Death (MeSH), Cell Nucleus (metabolism), Cloning, Molecular (MeSH), Europe (MeSH), Evolution, Molecular (MeSH), Fungal Proteins (chemistry), Fungal Proteins (genetics), Fungal Proteins (metabolism), Host-Pathogen Interactions (MeSH), Peronospora (classification), Peronospora (isolation & purification), Peronospora (metabolism), Phylogeny (MeSH), Plant Diseases (microbiology), Protein Domains (MeSH), Sequence Analysis, Protein (MeSH), Species Specificity (MeSH), Tobacco (microbiology), United States (MeSH), Vitis (microbiology).
- MESH :
- chemical , chemistry : Fungal Proteins.
- chemical , genetics : Fungal Proteins.
- chemical , metabolism : Fungal Proteins.
- geographic : Europe, United States.
- classification : Peronospora.
- isolation & purification : Peronospora.
- metabolism : Cell Nucleus, Peronospora.
- microbiology : Plant Diseases, Tobacco, Vitis.
- Cell Death, Cloning, Molecular, Evolution, Molecular, Host-Pathogen Interactions, Phylogeny, Protein Domains, Sequence Analysis, Protein, Species Specificity.
Abstract
Plasmopara viticola is a biotrophic oomycete pathogen causing grapevine downy mildew. We characterized the repertoire of P. viticola effector proteins which may be translocated into plants to support the disease. We found several secreted proteins that contain canonical dEER motifs and conserved WY-domains but lack the characteristic RXLR motif reported previously from oomycete effectors. We cloned four candidates and showed that one of them, Pv33, induces plant cell death in grapevine and Nicotiana species. This activity is dependent on the nuclear localization of the protein. Sequence similar effectors were present in seven European, but in none of the tested American isolates. Together our work contributes a new type of conserved P. viticola effector candidates.
DOI: 10.1371/journal.pone.0220184
PubMed: 31356604
PubMed Central: PMC6663016
Affiliations:
- France, Royaume-Uni
- Alsace (région administrative), Angleterre, Angleterre de l'Est, Grand Est
- Cambridge, Colmar
- Université de Cambridge, Université de Strasbourg
Links toward previous steps (curation, corpus...)
Le document en format XML
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Combier</name><affiliation wicri:level="4"><nlm:affiliation>SVQV, Université de Strasbourg, INRA, Colmar, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>SVQV, Université de Strasbourg, INRA, Colmar</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Colmar</settlement></placeName><orgName type="university">Université de Strasbourg</orgName></affiliation></author><author><name sortKey="Evangelisti, Edouard" sort="Evangelisti, Edouard" uniqKey="Evangelisti E" first="Edouard" last="Evangelisti">Edouard Evangelisti</name><affiliation wicri:level="4"><nlm:affiliation>University of Cambridge, Sainsbury Laboratory (SLCU), Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Sainsbury Laboratory (SLCU), Cambridge</wicri:regionArea><orgName type="university">Université de 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Rengel</name><affiliation wicri:level="1"><nlm:affiliation>LIPM Laboratoire des Interactions Plantes-Microorganismes, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>LIPM Laboratoire des Interactions Plantes-Microorganismes, Université de Toulouse, INRA, CNRS, Castanet-Tolosan</wicri:regionArea><wicri:noRegion>Castanet-Tolosan</wicri:noRegion><wicri:noRegion>Castanet-Tolosan</wicri:noRegion></affiliation></author><author><name sortKey="Legrand, Ludovic" sort="Legrand, Ludovic" uniqKey="Legrand L" first="Ludovic" last="Legrand">Ludovic Legrand</name><affiliation wicri:level="1"><nlm:affiliation>LIPM Laboratoire des Interactions Plantes-Microorganismes, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>LIPM Laboratoire des Interactions Plantes-Microorganismes, Université de Toulouse, INRA, CNRS, Castanet-Tolosan</wicri:regionArea><wicri:noRegion>Castanet-Tolosan</wicri:noRegion><wicri:noRegion>Castanet-Tolosan</wicri:noRegion></affiliation></author><author><name sortKey="Shenhav, Liron" sort="Shenhav, Liron" uniqKey="Shenhav L" first="Liron" last="Shenhav">Liron Shenhav</name><affiliation wicri:level="4"><nlm:affiliation>University of Cambridge, Sainsbury Laboratory (SLCU), Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Cambridge, Sainsbury Laboratory (SLCU), Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Bouchez, Olivier" sort="Bouchez, Olivier" uniqKey="Bouchez O" first="Olivier" last="Bouchez">Olivier Bouchez</name><affiliation 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nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Mestre, Pere" sort="Mestre, Pere" uniqKey="Mestre P" first="Pere" last="Mestre">Pere Mestre</name><affiliation wicri:level="4"><nlm:affiliation>SVQV, Université de Strasbourg, INRA, Colmar, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>SVQV, Université de Strasbourg, INRA, Colmar</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Colmar</settlement></placeName><orgName type="university">Université de Strasbourg</orgName></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Death (MeSH)</term><term>Cell Nucleus (metabolism)</term><term>Cloning, Molecular (MeSH)</term><term>Europe (MeSH)</term><term>Evolution, Molecular (MeSH)</term><term>Fungal Proteins (chemistry)</term><term>Fungal Proteins (genetics)</term><term>Fungal Proteins (metabolism)</term><term>Host-Pathogen Interactions (MeSH)</term><term>Peronospora (classification)</term><term>Peronospora (isolation & purification)</term><term>Peronospora (metabolism)</term><term>Phylogeny (MeSH)</term><term>Plant Diseases (microbiology)</term><term>Protein Domains (MeSH)</term><term>Sequence Analysis, Protein (MeSH)</term><term>Species Specificity (MeSH)</term><term>Tobacco (microbiology)</term><term>United States (MeSH)</term><term>Vitis (microbiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse de séquence de protéine (MeSH)</term><term>Clonage moléculaire (MeSH)</term><term>Domaines protéiques (MeSH)</term><term>Europe (MeSH)</term><term>Interactions hôte-pathogène (MeSH)</term><term>Maladies des plantes (microbiologie)</term><term>Mort cellulaire (MeSH)</term><term>Noyau de la cellule (métabolisme)</term><term>Peronospora (classification)</term><term>Peronospora (isolement et purification)</term><term>Peronospora (métabolisme)</term><term>Phylogenèse (MeSH)</term><term>Protéines fongiques (composition chimique)</term><term>Protéines fongiques (génétique)</term><term>Protéines fongiques (métabolisme)</term><term>Spécificité d'espèce (MeSH)</term><term>Tabac (microbiologie)</term><term>Vitis (microbiologie)</term><term>États-Unis (MeSH)</term><term>Évolution moléculaire (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fungal Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Fungal Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fungal Proteins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Peronospora</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Peronospora</term><term>Protéines fongiques</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines fongiques</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Peronospora</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Peronospora</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Nucleus</term><term>Peronospora</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des plantes</term><term>Tabac</term><term>Vitis</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Diseases</term><term>Tobacco</term><term>Vitis</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Noyau de la cellule</term><term>Peronospora</term><term>Protéines fongiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Death</term><term>Cloning, Molecular</term><term>Evolution, Molecular</term><term>Host-Pathogen Interactions</term><term>Phylogeny</term><term>Protein Domains</term><term>Sequence Analysis, Protein</term><term>Species Specificity</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Analyse de séquence de protéine</term><term>Clonage moléculaire</term><term>Domaines protéiques</term><term>Europe</term><term>Interactions hôte-pathogène</term><term>Mort cellulaire</term><term>Phylogenèse</term><term>Spécificité d'espèce</term><term>États-Unis</term><term>Évolution moléculaire</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plasmopara viticola is a biotrophic oomycete pathogen causing grapevine downy mildew. We characterized the repertoire of P. viticola effector proteins which may be translocated into plants to support the disease. We found several secreted proteins that contain canonical dEER motifs and conserved WY-domains but lack the characteristic RXLR motif reported previously from oomycete effectors. We cloned four candidates and showed that one of them, Pv33, induces plant cell death in grapevine and Nicotiana species. This activity is dependent on the nuclear localization of the protein. Sequence similar effectors were present in seven European, but in none of the tested American isolates. Together our work contributes a new type of conserved P. viticola effector candidates.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31356604</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>04</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>09</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>14</Volume><Issue>7</Issue><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS One</ISOAbbreviation></Journal><ArticleTitle>A secreted WY-domain-containing protein present in European isolates of the oomycete Plasmopara viticola induces cell death in grapevine and tobacco species.</ArticleTitle><Pagination><MedlinePgn>e0220184</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0220184</ELocationID><Abstract><AbstractText>Plasmopara viticola is a biotrophic oomycete pathogen causing grapevine downy mildew. We characterized the repertoire of P. viticola effector proteins which may be translocated into plants to support the disease. We found several secreted proteins that contain canonical dEER motifs and conserved WY-domains but lack the characteristic RXLR motif reported previously from oomycete effectors. We cloned four candidates and showed that one of them, Pv33, induces plant cell death in grapevine and Nicotiana species. This activity is dependent on the nuclear localization of the protein. Sequence similar effectors were present in seven European, but in none of the tested American isolates. Together our work contributes a new type of conserved P. viticola effector candidates.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Combier</LastName><ForeName>Maud</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>SVQV, Université de Strasbourg, INRA, Colmar, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Evangelisti</LastName><ForeName>Edouard</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>University of Cambridge, Sainsbury Laboratory (SLCU), Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Piron</LastName><ForeName>Marie-Christine</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>SVQV, Université de Strasbourg, INRA, Colmar, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rengel</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>LIPM Laboratoire des Interactions Plantes-Microorganismes, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Legrand</LastName><ForeName>Ludovic</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>LIPM Laboratoire des Interactions Plantes-Microorganismes, Université de Toulouse, INRA, CNRS, Castanet-Tolosan, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shenhav</LastName><ForeName>Liron</ForeName><Initials>L</Initials><Identifier Source="ORCID">0000-0003-1961-4187</Identifier><AffiliationInfo><Affiliation>University of Cambridge, Sainsbury Laboratory (SLCU), Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouchez</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>US 1426 GeT-PlaGe, Genotoul, INRA, Castanet-Tolosan, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schornack</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0002-7836-5881</Identifier><AffiliationInfo><Affiliation>University of Cambridge, Sainsbury Laboratory (SLCU), Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mestre</LastName><ForeName>Pere</ForeName><Initials>P</Initials><Identifier Source="ORCID">0000-0003-4488-6563</Identifier><AffiliationInfo><Affiliation>SVQV, Université de Strasbourg, INRA, Colmar, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>07</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005656">Fungal Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D016923" MajorTopicYN="N">Cell Death</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002467" MajorTopicYN="N">Cell Nucleus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003001" MajorTopicYN="N">Cloning, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="N">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005656" MajorTopicYN="N">Fungal 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MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000072417" MajorTopicYN="N">Protein Domains</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020539" MajorTopicYN="N">Sequence Analysis, Protein</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013045" MajorTopicYN="N">Species Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014026" MajorTopicYN="N">Tobacco</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D027843" MajorTopicYN="N">Vitis</DescriptorName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading></MeshHeadingList><CoiStatement>The authors have declared that no competing interests exist.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>05</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>07</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>7</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31356604</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0220184</ArticleId><ArticleId IdType="pii">PONE-D-19-12890</ArticleId><ArticleId IdType="pmc">PMC6663016</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Science. 2007 Feb 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|texte= A secreted WY-domain-containing protein present in European isolates of the oomycete Plasmopara viticola induces cell death in grapevine and tobacco species.
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